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Article

ZAP-70 expression is associated with enhanced ability to respond to migratory and survival signals in B-cell chronic lymphocytic leukemia (B-CLL).

Blood - 1 May 2006

Richardson Sarah J, Matthews Christine, Catherwood Mark A, Alexander H Denis, Carey B Sean, Farrugia Joanna, Gardiner Anne, Mould Sarah, Oscier David, Copplestone J Adrian, Prentice Archibald G

Abstract excerpt

Molecular markers like IgV(H) mutational status, chromosomal abnormalities, and CD38 and ZAP-70 expression have prognostic value in B-cell chronic lymphocytic leukemia (B-CLL). These may be pathogenetic because of the coincidental expression of ZAP-70 and increased B-cell receptor (BCR) signaling and the signaling function of CD38 in CLL. This study shows that ZAP-70(+) CLL B cells respond in vitro more readily...

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Source

Identifiers

PMID: 16332969
DOI: 10.1182/blood-2005-04-1718

Genes

CXCL12
BCR
CCL19
CCL21
CCR7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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ZAP-70 expression is associated with enhanced ability to respond to migratory and survival signals in B-cell chronic lymphocytic leukemia (B-CLL).PMID 16332969Read ↗

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