Article
Multidrug resistance phenotype in patients with chronic lymphocytic leukemia as detected by immunofluorescence (FACS) and northern blot analysis.
Leukemia research - 1 Jul 1994
Wulf G, Kluding H, Ho A D, Doerner M, Doehner H, Manegold C, Hunstein W
Abstract excerpt
The multidrug resistance (MDR) phenotype has been demonstrated to be related to the overexpression of P-glycoprotein, a 170 kDa transmembrane efflux pump. We studied P-glycoprotein expression in 40 patients with chronic B-cell leukemias by FACS analysis using MoAb c219, which recognizes both the...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Carrier Proteins
- Cell Cycle
- Drug Resistance
- Fluorescent Antibody Technique
- Gene Expression
- Humans
- Leukemia, Lymphocytic, Chronic, B-Cell
- Membrane Glycoproteins
- Phenotype
- RNA, Messenger
- RNA, Neoplasm
- Survival Analysis