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Article

Strong interferon-inducing capacity of a highly virulent variant of influenza A virus strain PR8 with deletions in the NS1 gene.

The Journal of general virology - 1 Dec 2009

Kochs Georg, Martínez-Sobrido Luis, Lienenklaus Stefan, Weiss Siegfried, García-Sastre Adolfo, Staeheli Peter

Abstract excerpt

Influenza viruses lacking the interferon (IFN)-antagonistic non-structural NS1 protein are strongly attenuated. Here, we show that mutants of a highly virulent variant of A/PR/8/34 (H1N1) carrying either a complete deletion or C-terminal truncations of NS1 were far more potent inducers of IFN in infected mice than NS1 mutants derived from standard A/PR/8/34. Efficient induction of IFN correlated with successful...

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Share to Influenza A Virus, H1N1 Subtype
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Inbred BALB C

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Source

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Identifiers

PMID: 19726611
DOI: 10.1099/vir.0.015727-0
PMCID: PMC2887554

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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