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Article

Viral Subpopulation Screening Guides in Designing a High Interferon-Inducing Live Attenuated Influenza Vaccine by Targeting Rare Mutations in NS1 and PB2 Proteins.

Journal of virology - 22 Dec 2020

Ghorbani Amir, Abundo Michael C, Ji Hana, Taylor Kara J M, Ngunjiri John M, Lee Chang-Won

Abstract excerpt

Influenza A viruses continue to circulate among wild birds and poultry worldwide, posing constant pandemic threats to humans. Effective control of emerging influenza viruses requires new broadly protective vaccines. Live attenuated influenza vaccines with truncations in nonstructural protein 1 (NS1) have shown broad protective efficacies in birds and mammals, which correlate with the ability to induce elevated...

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Source

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Identifiers

PMID: 33115873
DOI: 10.1128/JVI.01722-20
PMCID: PMC7944443

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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