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Influenza B Virus NS1-Truncated Mutants: Live-Attenuated Vaccine Approach

4 Sept 2008

Abstract excerpt

Type B influenza viruses can cause substantial morbidity and mortality in the population, and vaccination remains by far the best means of protection against infections with these viruses. Here, we report the construction of mutant influenza B viruses for potential use as improved live-virus vaccine candidates. Employing reverse genetics, we altered the NS1 gene, which encodes a type I interferon (IFN)...

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Identifiers

PMID: 18768976
DOI: 10.1128/jvi.01213-08

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