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Article

NS1-mediated delay of type I interferon induction contributes to influenza A virulence in ferrets

17 Mar 2011

Abstract excerpt

Interference of the influenza A virus non-structural protein NS1 with type I interferon (IFN) signalling has been characterized extensively in vitro. To assess the contribution of NS1 to the virulence of a specific strain, we generated recombinant USSR/90/77 viruses bearing the NS1 proteins of the attenuated strain PR/8/34 or the highly pathogenic strain 1918 'Spanish flu', all belonging to the H1N1 subtype. In...

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PMID: 21411677
DOI: 10.1099/vir.0.032193-0

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