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Article

D2I and F9Y Mutations in the NS1 Protein of Influenza A Virus Affect Viral Replication via Regulating Host Innate Immune Responses.

Viruses - 1 Jun 2022

Yu Mengqi, Guo Yanna, Zhao Lingcai, Lu Yuanlu, Liu Qingzheng, Li Yinjing, Deng Lulu, Shi Zhiyu, Wang Haifeng, Dankar Samar, Ping Jihui

Abstract excerpt

Influenza A viruses (IAV) modulate host antiviral responses to promote viral growth and pathogenicity. The non-structural (NS1) protein of influenza A virus has played an indispensable role in the inhibition of host immune responses, especially in limiting interferon (IFN) production. In this study, random site mutations were introduced into the NS1 gene of A/WSN/1933 (WSN, H1N1) via an error prone PCR to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35746676
DOI: 10.3390/v14061206
PMCID: PMC9228823

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