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Replication fitness determines high virulence of influenza A virus in mice carrying functional <i>Mx1</i> resistance gene

10 Apr 2007

Abstract excerpt

The IFN-induced resistance factor Mx1 is a critical component of innate immunity against influenza A viruses (FLUAV) in mice. Animals carrying a wild-type Mx1 gene (Mx1(+/+)) differ from regular laboratory mice (Mx1(-/-)) in that they are highly resistant to infection with standard FLUAV strains. We identified an extraordinary variant of the FLUAV strain, A/PR/8/34 (H1N1) (designated hvPR8), which is unusually...

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PMID: 17426143
DOI: 10.1073/pnas.0701849104

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