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Influenza A and B viruses expressing altered NS1 proteins: A vaccine approach

21 Mar 2000

Abstract excerpt

We propose a rational approach to the generation of live viral vaccines: alteration of virally encoded type I IFN antagonists to attenuate virulence while retaining immunogenicity. We have explored this concept by using the influenza virus. Previously we have shown that the NS1 protein of influenza A virus possesses anti-IFN activity. We now present evidence that influenza A and B viruses encoding altered viral...

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PMID: 10725408
DOI: 10.1073/pnas.070525997

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