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Article

Immunogenicity and protection efficacy of replication-deficient influenza A viruses with altered NS1 genes.

Journal of virology - 1 Dec 2004

Ferko Boris, Stasakova Jana, Romanova Julia, Kittel Christian, Sereinig Sabine, Katinger Hermann, Egorov Andrej

Abstract excerpt

We explored the immunogenic properties of influenza A viruses with altered NS1 genes (NS1 mutant viruses). NS1 mutant viruses expressing NS1 proteins with an impaired RNA-binding function or insertion of a longer foreign sequence did not replicate in murine lungs but still were capable of inducing a Th1-type immune response resulting in significant titers of virus-specific serum and mucosal immunoglobulin G2...

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Identifiers

PMID: 15542655
DOI: 10.1128/JVI.78.23.13037-13045.2004
PMCID: PMC524997

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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