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Article

Properties of H7N7 influenza A virus strain SC35M lacking interferon antagonist NS1 in mice and chickens

5 Apr 2007

Abstract excerpt

Non-structural protein NS1 of influenza A virus counteracts the host immune response by blocking the synthesis of type I interferon (IFN). As deletion of the complete NS1 gene has to date been reported only in the human H1N1 strain A/PR/8/34, it remained unclear whether NS1 is a non-essential virulence factor in other influenza A virus strains as well. In this report, the properties of NS1-deficient mutants...

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PMID: 17412966
DOI: 10.1099/vir.0.82764-0

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