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Article

Single-channel kinetic analysis for activation and desensitization of homomeric 5-HT(3)A receptors.

Biophysical journal - 2 Sept 2009

Corradi Jeremías, Gumilar Fernanda, Bouzat Cecilia

Abstract excerpt

The 5-HT(3)A receptor is a member of the Cys-loop family of ligand-gated ion channels. To perform kinetic analysis, we mutated the 5-HT3A subunit to obtain a high-conductance form so that single-channel currents can be detected. At all 5-HT concentrations (> 0.1 microM), channel activity appears as openings in quick succession that form bursts, which coalesce into clusters. By combining single-channel and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19720021
DOI: 10.1016/j.bpj.2009.06.018
PMCID: PMC2749742

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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