Article
A single channel mutation alters agonist efficacy at 5-HT3A and 5-HT3AB receptors.
British journal of pharmacology - 1 Sept 2013
Thompson A J, Lummis S C R
Abstract excerpt
BACKGROUND AND PURPOSE: 5-HT3 receptors are composed of 5-HT3A subunits (homomeric receptors), or combinations of 5-HT3A and other 5-HT3 receptor subunits (heteromeric receptors, the best studied of which are 5-HT3AB receptors). Here we explore the effects of partial agonists at 5-HT3A and 5-HT3AB receptors, and the importance of a channel-lining residue in determining the efficacy of activation. EXPERIMENTAL...
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