Article

Mapping the molecular motions of 5-HT <sub>3</sub> serotonin-gated channel by Voltage-Clamp Fluorometry

2023-09-28

Abstract excerpt

The serotonin-gated ion channel (5-HT 3 R) mediates excitatory neuronal communication in the gut and the brain. It is the target for setrons, a class of competitive antagonists widely used as antiemetics, and is involved in several neurological diseases. Cryo-electron microscopy of the 5-HT 3 R in complex with serotonin or setrons revealed that the protein has access to a wide conformational landscape. However,...

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Literature Corpus work: 1cce4817-da91-5a09-953b-0d6385a27433
DOI: 10.1101/2023.09.28.559960

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