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Article

Tricyclic antidepressants inhibit homomeric Cys-loop receptors by acting at different conformational states.

European journal of pharmacology - 14 Apr 2008

Gumilar Fernanda, Bouzat Cecilia

Abstract excerpt

Tricyclic antidepressants not only inhibit monoamine reuptake but also modulate Cys-loop receptors. However, it is not understood how this modulation is involved in their therapeutic effects. We analyzed the mechanisms of inhibition of homomeric 5-HT(3A) and alpha7-5HT(3A) receptors by tricyclic antidepressants at the single-channel and macroscopic current levels. These drugs reduce agonist-evoked currents in a...

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Source

Identifiers

PMID: 18314100
DOI: 10.1016/j.ejphar.2008.01.023

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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