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Article

Structural determinants of Ca2+ permeability and conduction in the human 5-hydroxytryptamine type 3A receptor.

The Journal of biological chemistry - 11 Jul 2008

Livesey Matthew R, Cooper Michelle A, Deeb Tarek Z, Carland Jane E, Kozuska Janna, Hales Tim G, Lambert Jeremy J, Peters John A

Abstract excerpt

Cation-selective cysteine (Cys)-loop transmitter-gated ion channels provide an important pathway for Ca2+ entry into neurones. We examined the influence on Ca2+ permeation of amino acids located at intra- and extracellular ends of the conduction pathway of the human 5-hydroxytryptamine type 3A (5-HT3A) receptor. Mutation of cytoplasmic arginine residues 432, 436, and 440 to glutamine, aspartate, and alanine (the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18474595
DOI: 10.1074/jbc.M802406200
PMCID: PMC2443672

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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