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Article

Pathways and Barriers for Ion Translocation through the 5-HT3A Receptor Channel.

PloS one - 1 Jan 2015

Di Maio Danilo, Chandramouli Balasubramanian, Brancato Giuseppe

Abstract excerpt

Pentameric ligand gated ion channels (pLGICs) are ionotropic receptors that mediate fast intercellular communications at synaptic level and include either cation selective (e.g., nAChR and 5-HT3) or anion selective (e.g., GlyR, GABAA and GluCl) membrane channels. Among others, 5-HT3 is one of the most studied members, since its first cloning back in 1991, and a large number of studies have successfully pinpointed...

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Identifiers

PMID: 26465896
DOI: 10.1371/journal.pone.0140258
PMCID: PMC4605793

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