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Article

Distinct p53 transcriptional programs dictate acute DNA-damage responses and tumor suppression.

Cell - 13 May 2011

Brady Colleen A, Jiang Dadi, Mello Stephano S, Johnson Thomas M, Jarvis Lesley A, Kozak Margaret M, Kenzelmann Broz Daniela, Basak Shashwati, Park Eunice J, McLaughlin Margaret E, Karnezis Anthony N, Attardi Laura D

Abstract excerpt

The molecular basis for p53-mediated tumor suppression remains unclear. Here, to elucidate mechanisms of p53 tumor suppression, we use knockin mice expressing an allelic series of p53 transcriptional activation mutants. Microarray analysis reveals that one mutant, p53(25,26), is severely compromi...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21565614
DOI: 10.1016/j.cell.2011.03.035
PMCID: PMC3259909

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21565614-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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