Article
Distinct p53 transcriptional programs dictate acute DNA-damage responses and tumor suppression.
Cell - 13 May 2011
Brady Colleen A, Jiang Dadi, Mello Stephano S, Johnson Thomas M, Jarvis Lesley A, Kozak Margaret M, Kenzelmann Broz Daniela, Basak Shashwati, Park Eunice J, McLaughlin Margaret E, Karnezis Anthony N, Attardi Laura D
Abstract excerpt
The molecular basis for p53-mediated tumor suppression remains unclear. Here, to elucidate mechanisms of p53 tumor suppression, we use knockin mice expressing an allelic series of p53 transcriptional activation mutants. Microarray analysis reveals that one mutant, p53(25,26), is severely compromised for transactivation of most p53 target genes, and, moreover, p53(25,26) cannot induce G(1)-arrest or apoptosis in...
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