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Article

Cell-type, dose, and mutation-type specificity dictate mutant p53 functions in vivo.

Cancer cell - 11 Dec 2012

Lee Ming Kei, Teoh Wei Wei, Phang Beng Hooi, Tong Wei Min, Wang Zhao Qi, Sabapathy Kanaga

Abstract excerpt

The specific roles of mutant p53's dominant-negative (DN) or gain-of-function (GOF) properties in regulating acute response and long-term tumorigenesis is unclear. Using "knockin" mouse strains expressing varying R246S mutant levels, we show that the DN effect on transactivation is universally observed after acute p53 activation, whereas the effect on cellular outcome is cell-type specific. Reducing mutant p53...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23238012
DOI: 10.1016/j.ccr.2012.10.022

Genes

MDM2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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