Article
p53 must be competent for transcriptional regulation to suppress tumor formation.
Oncogene - 19 May 2005
Nistér Monica, Tang Mengjia, Zhang Xiao-Qun, Yin Chaoying, Beeche Michelle, Hu Xinrong, Enblad Gunilla, van Dyke Terry, Wahl Geoffrey M
Abstract excerpt
In vitro studies suggest that effective tumor suppression by p53 requires multiple domains to execute transcription-dependent and transcription-independent functions. We generated a mutant p53 allele in mice, p53(W25QL26S) (p53(QS)), containing an inactive transactivation domain to evaluate the importance of transactivation for p53-mediated tumor suppression. Recently, we discovered that the allele also contains...
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