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Article

Functional analysis of 5-lipoxygenase promoter repeat variants.

Human molecular genetics - 1 Dec 2009

Vikman Susanna, Brena Romulo M, Armstrong Patrice, Hartiala Jaana, Stephensen Charles B, Allayee Hooman

Abstract excerpt

Variants of a hexanucleotide repeat polymorphism in the promoter of the 5-lipoxygenase (5-LO) gene have been associated with cardiovascular disease traits in humans, which may be due, at least in part, to differential expression of the at-risk alleles. To more fully characterize these variants, we carried out gene expression and DNA methylation studies in primary leukocytes from healthy individuals carrying...

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Identifiers

PMID: 19717473
DOI: 10.1093/hmg/ddp414
PMCID: PMC2773268

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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