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Article

Genetic insights into 5-LOX-activating protein: a narrative review of disease associations.

Human genomics - 13 Dec 2025

Rataj Katharina, Garscha Ulrike

Abstract excerpt

The 5-lipoxygenase-activating protein (FLAP) is an integral membrane protein that is essential for 5-lipoxygenase-mediated leukotriene formation, thereby playing a key role in inflammation and serving as a potential therapeutic target. For over 30 years, researchers have been elucidating the crystal structure, identifying the inhibitor binding site, and developing several potent inhibitors, which have been...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41390442
DOI: 10.1186/s40246-025-00867-x
PMCID: PMC12821811

Genes

ALOX5AP
LOX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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