Article
Naturally occurring mutations in the human 5-lipoxygenase gene promoter that modify transcription factor binding and reporter gene transcription.
The Journal of clinical investigation - 1 Mar 1997
In K H, Asano K, Beier D, Grobholz J, Finn P W, Silverman E K, Silverman E S, Collins T, Fischer A R, Keith T P, Serino K, Kim S W, De Sanctis G T, Yandava C, Pillari A, Rubin P, Kemp J, Israel E, Busse W, Ledford D, Murray J J, Segal A, Tinkleman D, Drazen J M
Abstract excerpt
Five lipoxygenase (5-LO) is the first committed enzyme in the metabolic pathway leading to the synthesis of the leukotrienes. We examined genomic DNA isolated from 25 normal subjects and 31 patients with asthma (6 of whom had aspirin-sensitive asthma) for mutations in the known transcription factor binding regions and the protein encoding region of the 5-LO gene. A family of mutations in the G + C-rich...
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