Article
Mutations in the human 5-lipoxygenase gene.
Clinical reviews in allergy & immunology - 1 Jan 2000
In K H, Silverman E S, Asano K, Beier D, Fischer A R, Keith T P, Serino K, Yandava C, De Sanctis G T, Drazen J M
Abstract excerpt
Our data demonstrate the presence of a naturally occurring family of alleles in the core promoter of the 5-LO gene, which is characterized by the deletion or addition of consensus Sp1 (-GGGCGG) and Egr-1 (-GCGGGGGCG-) binding motifs. Each of the variant alleles can bind Sp1 and Egr-1 protein, as indicated by EMSA and supershift analysis with nuclear extracts. In addition, preliminary data from CAT reporter assays...
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