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Article

Promoter polymorphism in the 5-lipoxygenase (ALOX5) and 5-lipoxygenase-activating protein (ALOX5AP) genes and asthma susceptibility in a Caucasian population.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Aug 2003

Sayers I, Barton S, Rorke S, Sawyer J, Peng Q, Beghé B, Ye S, Keith T, Clough J B, Holloway J W, Sampson A P, Holgate S T

Abstract excerpt

BACKGROUND: 5-Lipoxygenase (5-LO) and 5-lipoxygenase-activating protein (FLAP) are essential for cysteinyl-leukotriene (cys-LT) production, critical mediators in asthma. OBJECTIVE: We sought to identify novel promoter polymorphisms within the FLAP (ALOX5AP) gene promoter and test the role of thes...

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Identifiers

PMID: 12911785
DOI: 10.1046/j.1365-2222.2003.01733.x

Genes

ALOX5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-12911785-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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