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Article

Common polymorphisms of ALOX5 and ALOX5AP and risk of coronary artery disease.

Human genetics - 1 May 2008

Assimes Themistocles L, Knowles Joshua W, Priest James R, Basu Analabha, Volcik Kelly A, Southwick Audrey, Tabor Holly K, Hartiala Jaana, Allayee Hooman, Grove Megan L, Tabibiazar Raymond, Sidney Stephen, Fortmann Stephen P, Go Alan, Hlatky Mark, Iribarren Carlos, Boerwinkle Eric, Myers Richard, Risch Neil, Quertermous Thomas

Abstract excerpt

Recent human genetic studies suggest that allelic variants of leukotriene pathway genes influence the risk of clinical and subclinical atherosclerosis. We sequenced the promoter, exonic, and splice site regions of ALOX5 and ALOX5AP and then genotyped 7 SNPs in ALOX5 and 6 SNPs in ALOX5AP in 1,552 cases with clinically significant coronary artery disease (CAD) and 1,583 controls from Kaiser Permanente including a...

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Identifiers

PMID: 18369664
DOI: 10.1007/s00439-008-0489-5
PMCID: PMC4023692

Genes

ALOX5
CAD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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