Article
Molecular analysis of Ku redox regulation.
BMC molecular biology - 28 Aug 2009
Bennett Sara M, Neher Tracy M, Shatilla Andrea, Turchi John J
Abstract excerpt
BACKGROUND: DNA double-strand breaks (DSBs) can occur in response to ionizing radiation (IR), radiomimetic agents and from endogenous DNA-damaging reactive oxygen metabolites. Unrepaired or improperly repaired DSBs are potentially the most lethal form of DNA damage and can result in chromosomal translocations and contribute to the development of cancer. The principal mechanism for the repair of DSBs in humans is...
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