Article
Mutation in the glucose-6-phosphate dehydrogenase gene leads to inactivation of Ku DNA end binding during oxidative stress.
The Journal of biological chemistry - 22 Mar 2002
Ayene Iraimoudi S, Stamato Thomas D, Mauldin Stanley K, Biaglow John E, Tuttle Steven W, Jenkins Susan F, Koch Cameron J
Abstract excerpt
Glucose-6-phosphate dehydrogenase (G6PD), the rate-limiting enzyme of the oxidative pentose phosphate cycle, regulates the NADPH/NADP(+) ratio in eukaryotic cells. G6PD deficiency is one of the most common mutations in humans and is known to cause health problems for hundreds of millions worldwide. Although it is known that decreased G6PD functionality can result in increased susceptibility to oxidative stress,...
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