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Article

Ku80-deleted cells are defective at base excision repair.

Mutation research - 1 Jan 2000

Li Han, Marple Teresa, Hasty Paul

Abstract excerpt

Ku80 forms a heterodimer with Ku70, called Ku, that repairs DNA double-strand breaks (DSBs) via the nonhomologous end joining (NHEJ) pathway. As a consequence of deleting NHEJ, Ku80-mutant cells are hypersensitive to agents that cause DNA DSBs like ionizing radiation. Here we show that Ku80 deletion also decreased resistance to ROS and alkylating agents that typically cause base lesions and single-strand breaks...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23567907
DOI: 10.1016/j.mrfmmm.2013.03.010
PMCID: PMC3721509

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Ku80-deleted cells are defective at base excision repair.PMID 23567907Read ↗

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