Article
Exploring genetic interactions and networks with yeast.
Nature reviews. Genetics - 1 Jun 2007
Boone Charles, Bussey Howard, Andrews Brenda J
Abstract excerpt
The development and application of genetic tools and resources has enabled a partial genetic-interaction network for the yeast Saccharomyces cerevisiae to be compiled. Analysis of the network, which is ongoing, has already provided a clear picture of the nature and scale of the genetic interactions that robustly sustain biological systems, and how cellular buffering is achieved at the molecular level. Recent...
Topics
- Algorithms
- Chromosome Mapping
- Diploidy
- Epistasis, Genetic
- Gene Deletion
- Genes, Lethal
- Genome, Fungal
- Genomics
- Models, Genetic
- Mutation
- Oligonucleotide Array Sequence Analysis
- Phenotype