Modelling genotype-phenotype relationships and human disease with genetic interaction networks.

Abstract excerpt

Probably all heritable traits, including disease susceptibility, are affected by interactions between mutations in multiple genes. We understand little, however, about how genes interact to produce phenotypes, and there is little power to detect interactions between genes in human population studies. An alternative approach towards understanding how mutations combine to produce phenotypes is to construct...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Caenorhabditis elegans
• Share to Genetic Diseases, Inborn
• Share to Genotype