Article
Derivation of genetic interaction networks from quantitative phenotype data.
Genome biology - 1 Jan 2005
Drees Becky L, Thorsson Vesteinn, Carter Gregory W, Rives Alexander W, Raymond Marisa Z, Avila-Campillo Iliana, Shannon Paul, Galitski Timothy
Abstract excerpt
We have generalized the derivation of genetic-interaction networks from quantitative phenotype data. Familiar and unfamiliar modes of genetic interaction were identified and defined. A network was derived from agar-invasion phenotypes of mutant yeast. Mutations showed specific modes of genetic interaction with specific biological processes. Mutations formed cliques of significant mutual information in their...
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