Article
High-Throughput Quantitative Genetic Interaction Mapping in the Fission Yeast Schizosaccharomyces pombe.
Cold Spring Harbor protocols - 1 Feb 2018
Roguev Assen, Ryan Colm J, Hartsuiker Edgar, Krogan Nevan J
Abstract excerpt
Epistasis mapping, in which the phenotype that emerges from combining pairs of mutations is measured quantitatively, is a powerful tool for unbiased study of gene function. When performed at a large scale, this approach has been used to assign function to previously uncharacterized genes, define functional modules and pathways, and study their cross talk. These experiments rely heavily on methods for rapid...
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