Global mapping of the yeast genetic interaction network.

doi:10.1126/science.1091317

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Article

Global mapping of the yeast genetic interaction network.

Science (New York, N.Y.) - 6 Feb 2004

Tong Amy Hin Yan, Lesage Guillaume, Bader Gary D, Ding Huiming, Xu Hong, Xin Xiaofeng, Young James, Berriz Gabriel F, Brost Renee L, Chang Michael, Chen YiQun, Cheng Xin, Chua Gordon, Friesen Helena, Goldberg Debra S, Haynes Jennifer, Humphries Christine, He Grace, Hussein Shamiza, Ke Lizhu, Krogan Nevan, Li Zhijian, Levinson Joshua N, Lu Hong, Ménard Patrice, Munyana Christella, Parsons Ainslie B, Ryan Owen, Tonikian Raffi, Roberts Tania, Sdicu Anne-Marie, Shapiro Jesse, Sheikh Bilal, Suter Bernhard, Wong Sharyl L, Zhang Lan V, Zhu Hongwei, Burd Christopher G, Munro Sean, Sander Chris, Rine Jasper, Greenblatt Jack, Peter Matthias, Bretscher Anthony, Bell Graham, Roth Frederick P, Brown Grant W, Andrews Brenda, Bussey Howard, Boone Charles

Abstract excerpt

A genetic interaction network containing approximately 1000 genes and approximately 4000 interactions was mapped by crossing mutations in 132 different query genes into a set of approximately 4700 viable gene yeast deletion mutants and scoring the double mutant progeny for fitness defects. Network connectivity was predictive of function because interactions often occurred among functionally related genes, and...

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PMID: 14764870
DOI: 10.1126/science.1091317

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