Article
Conserved rules govern genetic interaction degree across species.
Genome biology - 2 Jul 2012
Koch Elizabeth N, Costanzo Michael, Bellay Jeremy, Deshpande Raamesh, Chatfield-Reed Kate, Chua Gordon, D'Urso Gennaro, Andrews Brenda J, Boone Charles, Myers Chad L
Abstract excerpt
BACKGROUND: Synthetic genetic interactions have recently been mapped on a genome scale in the budding yeast Saccharomyces cerevisiae, providing a functional view of the central processes of eukaryotic life. Currently, comprehensive genetic interaction networks have not been determined for other species, and we therefore sought to model conserved aspects of genetic interaction networks in order to enable the...
Topics
- Evolution, Molecular
- Gene Regulatory Networks
- Genes, Fungal
- Genetic Fitness
- Models, Genetic
- Mutation
- Saccharomyces cerevisiae
- Schizosaccharomyces
- Species Specificity