Article
Paraoxonase (PON1) and the risk for coronary heart disease and myocardial infarction in a general population of Dutch women.
Atherosclerosis - 1 Aug 2008
van Himbergen Thomas M, van der Schouw Yvonne T, Voorbij Hieronymus A M, van Tits Lambertus J H, Stalenhoef Anton F H, Peeters Petra H M, Roest Mark
Abstract excerpt
There is strong evidence from both animal- and in vitro-models that paraoxonase (PON1) is involved in the onset of cardiovascular disease. In humans there is no consensus on this issue and therefore we investigated the effect of PON1 genotype and activity on the incidence of coronary heart disease (CHD) and acute myocardial infarction (AMI) in a large prospective cohort of 17,357 middle-aged women. We applied a...
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