Molecular basis of genetic variation in debrisoquin hydroxylation in Chinese subjects: polymorphism in RFLP and DNA sequence of CYP2D6.

doi:10.1038/clpt.1993.44

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Molecular basis of genetic variation in debrisoquin hydroxylation in Chinese subjects: polymorphism in RFLP and DNA sequence of CYP2D6.

Clinical pharmacology and therapeutics - 1 Apr 1993

Wang S L, Huang J D, Lai M D, Liu B H, Lai M L

Abstract excerpt

Debrisoquin hydroxylation phenotype was determined in 124 Chinese persons living in Taiwan, and two poor metabolizers were identified with a urinary metabolic ratio (MR) greater than 12.6. The other subjects, extensive metabolizers, showed a normal frequency distribution of log(MR). Most subjects (50%) showed a 44/29 kb pattern in restriction fragment length polymorphism (RFLP) analysis with use of Xba I, and 30%...

Topics

Adult
Asian People
Base Sequence
China
Cytochrome P-450 CYP2D6
Cytochrome P-450 Enzyme System
DNA
Debrisoquin
Female
Genotype
Homozygote

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Hydroxylation

Male

Middle Aged

Mixed Function Oxygenases

Molecular Sequence Data

Mutation

Source

Open in PubMed

Identifiers

PMID: 8097442
DOI: 10.1038/clpt.1993.44

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8097442-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular basis of genetic variation in debrisoquin hydroxylation in Chinese subjects: polymorphism in RFLP and DNA sequence of CYP2D6.PMID 8097442Read ↗

G169R mutation diminishes the metabolic activity of CYP2D6 in Chinese.Semantic proximity Read ↗

Genetic analysis of the CYP2D locus in relation to debrisoquine hydroxylation capacity in Korean, Japanese and Chinese subjects.Semantic proximity Read ↗

Debrisoquine and S-mephenytoin hydroxylation phenotypes and genotypes in a Korean population.Semantic proximity Read ↗

Debrisoquine/sparteine hydroxylation genotype and phenotype: analysis of common mutations and alleles of CYP2D6 in a European population.Semantic proximity Read ↗

CYP2D6 phenotype-genotype relationships in African-Americans and Caucasians in Los Angeles.Semantic proximity Read ↗

Analysis of the CYP2D6 gene in relation to debrisoquin and desipramine hydroxylation in a Swedish population.Semantic proximity Read ↗

Debrisoquine oxidation polymorphism: phenotypic consequences of a 3-base-pair deletion in exon 5 of the CYP2D6 gene.Semantic proximity Read ↗

Pharmacogenetics of Debrisoquine and its Use as a Marker For CYP2D6 Hydroxylation CapacitySemantic proximity Read ↗

CYP2D6 phenotypes among Malays in Malaysia.Semantic proximity Read ↗

The debrisoquine metabolic phenotype and DNA-based assays: implications of misclassification for the association of lung cancer and the debrisoquine metabolic phenotype.Semantic proximity Read ↗

Human debrisoquine hydroxylase gene polymorphisms in cancer patients and controls.Semantic proximity Read ↗

Genetic basis for differences in debrisoquin polymorphism between a Spanish and other white populations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.