Article
Lower prevalence of the debrisoquin oxidative poor metabolizer phenotype in American black versus white subjects.
Clinical pharmacology and therapeutics - 1 Sept 1991
Relling M V, Cherrie J, Schell M J, Petros W P, Meyer W H, Evans W E
Abstract excerpt
Our objective was to determine whether there are differences in debrisoquin hydroxylase (P450IID6) activity between American black subjects and white subjects. Phenotype was assigned in a group of 586 unrelated white and black children with use of dextromethorphan as the substrate probe. Restriction fragment length polymorphism analysis of genomic deoxyribonucleic acid (DNA) was performed in a subset of subjects...
Topics
- Black People
- Child
- Cytochrome P-450 Enzyme System
- DNA
- Debrisoquin
- Dextromethorphan
- Dextrorphan
- Female
- Humans
- Phenotype
- Polymorphism, Restriction Fragment Length