Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An HIV-1 resistance polymorphism in TRIM5α gene among Chinese intravenous drug users.

Journal of acquired immune deficiency syndromes (1999) - 1 Apr 2011

Liu Feng-Liang, Qiu Yu-Qing, Li Hong, Kuang Yi-Qun, Tang Xia, Cao Guang, Tang Nelson Leung Sang, Zheng Yong-Tang

Abstract excerpt

BACKGROUND: TRIM5α has species-specific restriction activity against replication of many retroviruses, including HIV-1. Though human also express TRIM5α protein, it is less potent in suppressing infection of HIV-1 than most orthologs of other nonhuman primates. Previous association studies suggested that polymorphisms in TRIM5α gene might protect against HIV-1 infection. However, the exact variation accounting...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Substitution
Share to Asian People

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carrier Proteins

Share to HIV Infections

Share to Immunity, Innate

Share to Substance Abuse, Intravenous

Share to Tripartite Motif Proteins

Share to Ubiquitin-Protein Ligases

Source

Identifiers

PMID: 21107267
DOI: 10.1097/QAI.0b013e318205a59b

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An HIV-1 resistance polymorphism in TRIM5α gene among Chinese intravenous drug users.PMID 21107267Read ↗

TRIM5α H43Y Polymorphism and Susceptibility to HIV-1 Infection: A Meta-Analysis.Semantic proximity Read ↗

Impact of novel TRIM5alpha variants, Gly110Arg and G176del, on the anti-HIV-1 activity and the susceptibility to HIV-1 infection.Semantic proximity Read ↗

Genetic association of the antiviral restriction factor TRIM5alpha with human immunodeficiency virus type 1 infection.Semantic proximity Read ↗

Effects of human TRIM5alpha polymorphisms on antiretroviral function and susceptibility to human immunodeficiency virus infection.Semantic proximity Read ↗

The effects of TRIM5α polymorphism on HIV-2ROD and SIVmac239 replication in PBMCs from Chinese rhesus macaques and Vietnamese-origin cynomolgus macaques.Semantic proximity Read ↗

A SDF1 genetic variant confers resistance to HIV-1 infection in intravenous drug users in China.Semantic proximity Read ↗

Effect of CYP2B6 Gene Polymorphisms on Efavirenz Plasma Concentrations in Chinese Patients with HIV Infection.Semantic proximity Read ↗

Wild type and H43Y variant of human TRIM5alpha show similar anti-human immunodeficiency virus type 1 activity both in vivo and in vitro.Semantic proximity Read ↗

Gene polymorphisms in CCR5, CCR2, SDF1 and RANTES among Chinese Han population with HIV-1 infection.Semantic proximity Read ↗

TRIM5 gene polymorphisms in HIV-1-infected patients and healthy controls from Northeastern Brazil.Semantic proximity Read ↗

The effect of Trim5 polymorphisms on the clinical course of HIV-1 infection.Semantic proximity Read ↗

The effect of TRIM5 variants on the susceptibility to HIV-1 infection and disease progression in the Polish population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.