Article
Ancient and recent adaptive evolution in the antiviral TRIM22 gene: identification of a single-nucleotide polymorphism that impacts TRIM22 function.
Human mutation - 1 Sept 2014
Kelly Jenna N, Woods Matthew W, Xhiku Sintia, Barr Stephen D
Abstract excerpt
Tripartite motif protein 22 (TRIM22) is a novel interferon-induced protein that potently inhibits the replication of evolutionarily diverse viruses, including HIV-1. Altered TRIM22 expression is also associated with diseases, such as multiple sclerosis, cancer, and autoimmunity. The factors that influence TRIM22 expression and antiviral activity are largely unknown. In this study, we adopted an evolution-guided...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.