Article
Effects of maternal genotype and diet on offspring glucose and fatty acid-sensing ventromedial hypothalamic nucleus neurons.
American journal of physiology. Regulatory, integrative and comparative physiology - 1 Nov 2009
Le Foll Christelle, Irani Boman G, Magnan Christophe, Dunn-Meynell Ambrose, Levin Barry E
Abstract excerpt
Maternal obesity accentuates offspring obesity in dams bred to develop diet-induced obesity (DIO) on a 31% fat, high-sucrose, high-energy (HE) diet but has no effect on offspring of diet-resistant (DR) dams. Also, only DIO dams become obese when they and DR dams are fed HE diet throughout gestation and lactation. We assessed glucose and oleic acid (OA) sensitivity of dissociated ventromedial hypothalamic nucleus...
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