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Article

Hypothalamic neural projections are permanently disrupted in diet-induced obese rats.

Cell metabolism - 1 Feb 2008

Bouret Sebastien G, Gorski Judith N, Patterson Christa M, Chen Stephen, Levin Barry E, Simerly Richard B

Abstract excerpt

The arcuate nucleus of the hypothalamus (ARH) is a key component of hypothalamic pathways regulating energy balance, and leptin is required for normal development of ARH projections. Diet-induced obesity (DIO) has a polygenic mode of inheritance, and DIO individuals develop the metabolic syndrome when a moderate amount of fat is added to the diet. Here we demonstrate that rats selectively bred to develop DIO,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18249177
DOI: 10.1016/j.cmet.2007.12.001
PMCID: PMC2442478

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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