Article
F-DIO obesity-prone rat is insulin resistant before obesity onset.
American journal of physiology. Regulatory, integrative and comparative physiology - 1 Sept 2005
Levin Barry E, Magnan Christophe, Migrenne Stephanie, Chua Streamson C, Dunn-Meynell Ambrose A
Abstract excerpt
We previously created a novel F-DIO rat strain derived by crossing rats selectively bred for the diet-induced obesity (DIO) phenotype with obesity-resistant Fischer F344 rats. The offspring retained the DIO phenotype through 3 backcrosses with F344 rats but also had exaggerated insulin responses to oral glucose before they became obese on a 31% fat high-energy (HE) diet. Here, we demonstrate that chow-fed rats...
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