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Article

Serotonergic dorsal raphe neurons from obese zucker rats are hyperexcitable.

Neuroscience - 1 Jan 2003

Ohliger-Frerking P, Horwitz B A, Horowitz J M

Abstract excerpt

Release of serotonin (5-HT) from dorsal raphe nucleus (DRN) neurons projecting to the ventromedial hypothalamus (VMH) has a modulatory effect on the neural pathway involved in feeding, hunger, and satiety. The obese Zucker rat, an animal model of genetic obesity, exhibits differences in serotonin signaling as well as a mutated leptin receptor. To evaluate possible mechanisms underlying this difference in...

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Identifiers

PMID: 12895503
DOI: 10.1016/s0306-4522(03)00360-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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