Article
Cyclin D1 gene polymorphism and familial prostate cancer: the AA genotype of A870G polymorphism is associated with prostate cancer risk in men aged 70 years or older and metastatic stage.
Anticancer research - 1 Jan 2000
Koike Hidekazu, Suzuki Kazuhiro, Satoh Tetsuo, Ohtake Nobuaki, Takei Tomoyuki, Nakata Seiji, Yamanaka Hidetoshi
Abstract excerpt
BACKGROUND: Cyclin D1 is a key protein involved in cell cycle regulation. A common A870G single nucleotide polymorphism in exon 4 of the cyclin D1 gene (CCND1) has an effect on the transcription of two different cyclin D1 mRNAs. Association of the genetic polymorphism of A870G of CCND1 with several cancer risks has been reported. MATERIALS AND METHODS: We performed a case-control study consisting of 99 familial...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.