Article
Enhanced skin carcinogenesis and lack of thymus hyperplasia in transgenic mice expressing human cyclin D1b (CCND1b).
Molecular carcinogenesis - 1 Jun 2009
Rojas Paola, Benavides Fernando, Blando Jorge, Perez Carlos, Cardenas Kim, Richie Ellen, Knudsen Erik S, Johnson David G, Senderowicz Adrian M, Rodriguez-Puebla Marcelo L, Conti Claudio J
Abstract excerpt
Cyclin D1b is an alternative transcript of the cyclin D1 gene (CCND1) expressed in human tumors. Its abundance is regulated by a single base pair polymorphism at the exon 4/intron 4 boundary (nucleotide 870). Epidemiological studies have shown a correlation between the presence of the G870A allele (that favors the splicing for cyclin D1b) with increased risk and less favorable outcome in several forms of cancer....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.