Article
Aberrant Cyclin D1 splicing in cancer: from molecular mechanism to therapeutic modulation.
Cell death & disease - 6 Apr 2023
Wang Jing, Su Wei, Zhang Taotao, Zhang Shasha, Lei Huiwen, Ma Fengdie, Shi Maoning, Shi Wenjing, Xie Xiaodong, Di Cuixia
Abstract excerpt
Cyclin D1 (CCND1), a crucial mediator of cell cycle progression, possesses many mutation types with different mutation frequencies in human cancers. The G870A mutation is the most common mutation in CCND1, which produces two isoforms: full-length CCND1a and divergent C-terminal CCND1b. The dysregulation of the CCND1 isoforms is associated with multiple human cancers. Exploring the molecular mechanism of CCND1...
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