Article
Genome-wide location analysis reveals a role for Sub1 in RNA polymerase III transcription.
Proceedings of the National Academy of Sciences of the United States of America - 25 Aug 2009
Tavenet Arounie, Suleau Audrey, Dubreuil Géraldine, Ferrari Roberto, Ducrot Cécile, Michaut Magali, Aude Jean-Christophe, Dieci Giorgio, Lefebvre Olivier, Conesa Christine, Acker Joël
Abstract excerpt
Human PC4 and the yeast ortholog Sub1 have multiple functions in RNA polymerase II transcription. Genome-wide mapping revealed that Sub1 is present on Pol III-transcribed genes. Sub1 was found to interact with components of the Pol III transcription system and to stimulate the initiation and reinitiation steps in a system reconstituted with all recombinant factors. Sub1 was required for optimal Pol III gene...
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