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Article

New suppressors of THO mutations identify Thp3 (Ypr045c)-Csn12 as a protein complex involved in transcription elongation.

Molecular and cellular biology - 1 Feb 2011

Jimeno Sonia, Tous Cristina, García-Rubio María L, Ranes Michael, González-Aguilera Cristina, Marín Antonio, Aguilera Andrés

Abstract excerpt

Formation of a ribonucleoprotein particle (mRNP) competent for export requires the coupling of transcription with mRNA processing and RNA export. A key link between these processes is provided by the THO complex. To progress in our understanding of this coupling, we have performed a search for suppressors of the transcription defect caused by the hpr1Δ mutation. This has permitted us to identify mutations in the...

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Identifiers

PMID: 21149575
DOI: 10.1128/MCB.01188-10
PMCID: PMC3028642

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