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Article

Yeast SUB1 is a suppressor of TFIIB mutations and has homology to the human co-activator PC4.

The EMBO journal - 15 Apr 1996

Knaus R, Pollock R, Guarente L

Abstract excerpt

Activation of transcription in eukaryotes depends upon the interplay between transcriptional activators and general transcription factors. While direct contacts between activators and general factors have been demonstrated in vitro, an additional class of proteins, termed co-activators, is also required of transcriptional activation. Here we describe a yeast protein, SUB1, that was isolated as a suppressor of the...

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Identifiers

PMID: 8617240
PMCID: PMC450112

Genes

SUB1
TBP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Yeast SUB1 is a suppressor of TFIIB mutations and has homology to the human co-activator PC4.PMID 8617240Read ↗

Genome-wide location analysis reveals a role for Sub1 in RNA polymerase III transcription.Semantic proximity Read ↗

Transcriptional repression of the IMD2 gene mediated by the transcriptional co-activator Sub1.Semantic proximity Read ↗

Sub1 globally regulates RNA polymerase II C-terminal domain phosphorylation.Semantic proximity Read ↗

DEAD-box RNA helicase Sub2 is required for expression of lacZ fusions in Saccharomyces cerevisiae and is a dosage-dependent suppressor of RLR1 (THO2).Semantic proximity Read ↗

Mutational analysis of yeast TFIIB. A functional relationship between Ssu72 and Sub1/Tsp1 defined by allele-specific interactions with TFIIB.Semantic proximity Read ↗

TFIIA has activator-dependent and core promoter functions in vivo.Semantic proximity Read ↗

The Saccharomyces cerevisiae Cdc68 transcription activator is antagonized by San1, a protein implicated in transcriptional silencing.Semantic proximity Read ↗

A mutation in the second largest subunit of TFIIIC increases a rate-limiting step in transcription by RNA polymerase III.Semantic proximity Read ↗

Identification of the gene (SSU71/TFG1) encoding the largest subunit of transcription factor TFIIF as a suppressor of a TFIIB mutation in Saccharomyces cerevisiae.Semantic proximity Read ↗

SPN1, a conserved gene identified by suppression of a postrecruitment-defective yeast TATA-binding protein mutant.Semantic proximity Read ↗

A novel subunit of yeast RNA polymerase III interacts with the TFIIB-related domain of TFIIIB70.Semantic proximity Read ↗

Intramolecular interaction of yeast TFIIB in transcription control.Semantic proximity Read ↗

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